G Dave Singh
BioModeling Solutions, Inc., USA
Title: Effect of biomimetic oral appliance therapy in adults with OSA
Biography
Biography: G Dave Singh
Abstract
Biomimetic oral appliance therapy (BOAT) represents an alternative to continuous positive airway pressure or mandibularrnadvancement devices for treating obstructive sleep apnea (OSA) in adults. Th erefore, we tested the hypothesis that the upperrnairway can be improved in adults diagnosed with mild, moderate and severe OSA using BOAT. For this study, we recruited 17rnconsecutive adults aged >21 yrs diagnosed with OSA aft er an overnight sleep study that was interpreted by a sleep physician.rnTh e mean apnea-hypopnea index (AHI) of the sample was calculated prior to and aft er BOAT and the fi ndings was subjected tornstatistical analysis using paired T-tests. In this study, 9 subjects were diagnosed with mild to moderate OSA (mOSA; AHI<30)rnand 8 subjects with severe OSA (sOSA; AHI>30). Prior to treatment, the mean AHI was 13.2 ± 7.2 for the mOSA group. Th ernmean treatment time was 8.7 mos. ± 5.8 and the mean AHI fell by 66% to 4.5 ±3.6 (p=0.002) aft er BOAT. For the sOSA group,rnthe mean treatment time was 10.4 mos. ± 2.6 and the mean, pre-treatment AHI was 46.6±12.0. Aft er BOAT for the sOSA group,rnthe mean AHI fell by 70% to 13.9±10.5 (p=0.001). Th is study supports the notion that BOAT may be successful in reducing thernAHI in adults diagnosed with mild, moderate and severe OSA. However, long-term follow up and larger sample sizes are neededrnto determine whether these initial upper airway improvements can be maintained.